Among these 33, the top six cancer types with the highest amplification frequency of YAP/TAZ included all five squamous cell-involved cancers (lung squamous cell carcinoma, esophageal squamous cell carcinoma, head and neck squamous cell carcinomas, and bladder urothelial carcinoma), whereas the frequency in PDAC was about 2% and 14th among 33 cancer types (64). The gene discussed is YAP1; the disease is cancer.