found that YAP regulates PD-L1 by directly binding to the PD-L1 promoter and that YAP/PD-L1 signaling modulated tumor cell proliferation and migration in EGFR–TKI-resistant lung adenocarcinoma, and also that YAP down-regulation inhibited PD-L1 expression (106). Here, CD274 is linked to lung adenocarcinoma.