AFP and hepatocellular carcinoma: Univariate and multivariate Cox regression analyses conducted on HCC patients with type I and II PVTT after R0 LR demonstrated that type of PVTT (P=0.001), INR level (P<0.001), AFP (P<0.001), tumor diameter (P=0.011), and direct bilirubin (P<0.001) to be independent predictors of OS (Table 2).