In addition, the review hopes to also touch on how our perspectives of LIF-LIFR signaling have grown more nuanced—with the addition of signaling pathways such as the Hippo pathway, the possible overlap with other LIFR ligands, the mechanisms through which LIF and LIFR have been classified as either pro-tumor growth/metastasis, or tumor growth/metastasis suppressive. This evidence concerns the gene LIF and neoplasm.