YAP1 and nasopharyngeal carcinoma: To further the complexity, in a model of nasopharyngeal carcinoma (NPC), cells constitutively expressing a cytoplasmic variant of LIF had a markedly lower expression of YAP as well as phosphorylated YAP at ser127, suggesting that although YAP expression was decreased, a higher proportion of YAP remained active relative to controls (46).