In Ptch1+/−/Tis21KO tumor biopsy samples the mean percentage of phosphorylated AKT (at Ser473) normalized to total AKT was not significantly increased when compared with the same value found in the Ptch1+/−/Tis21WT MBs (p = 0.7774; Student’s t‐test, Figure 3B), probably because of the variability between tumors. Here, PTCH1 is linked to neoplasm.