Of note, in addition to AKT phosphorylation, the mTOR/S6K signaling could also be responsible for the increase in cell survival observed in Ptch1+/−/Tis21KO MBs, by its positive impact on protein translation (87) or by direct inhibitory phosphorylation of the pro-apoptotic protein BAD (88). The gene discussed is RPS6KB1; the disease is Mobius syndrome.