AKT1 and cancer: It is known that in different human cancers Btg2 (human ortholog of the mouse gene Tis21) inhibits the processes of cell proliferation, survival and metastasis by suppressing the PI3K/AKT/mTOR pathway, since the Btg2 protein acts as a negative regulator of AKT in both tumor cells (80–82) and normal ones (83, 84).