The possible mechanism by which this leads to radiation protection is activation of PTEN and inactivation of AKT (25). Luteolin is an active flavonoid compound with anti-oxidative, anti-inflammatory, and anti-fibrotic properties, which also alleviates collagen deposition, TGF-β1 expression, and lung fibrosis (26). This evidence concerns the gene PTEN and pulmonary fibrosis.