The data showed 75% of recurrent prostate cancer were positive and detection rates increased with PSA: 38% for <0.5 ng/mL, 57% for 0.5 to <1.0 ng/mL, 84% for 1.0 to <2.0 ng/mL, 86% for 2.0 to <5.0 ng/mL (n = 158), and 97% for ≥5.0 ng/mL (n = 173, P <.001) (65). This evidence concerns the gene KLK3 and Familial prostate cancer.