In the detection of primary and metastatic prostate cancer, the overall sensitivity and specificity of 68Ga-PSMA PET/CT are significantly higher than 18F-FDG PET/CT, but this does not mean that PSMA PET/CT has an excellent performance in all types of prostate cancer and all clinical environments, on the contrary, 18F-FDG plays a crucial role in CRPC and NEPC. This evidence concerns the gene FOLH1 and Familial prostate cancer.