In over 90% of lung cancers, the cell cycle occurs as dysregulation, which makes the derangements of cell cycle mediators in the expression and/or activation, especially within the CDK–cyclin–RB pathways, and is integrally involved in malignant transformation and tumor progression, destroying the cell proliferation mechanism controlling the growth of advanced NSCLC (3–5). This evidence concerns the gene RB1 and non-small cell lung carcinoma.