Similar to our recent findings of lncRNA ELFN1-AS1 (30), the finding of increased E-cadherin accompanied by decreased N-cadherin and vimentin in lncRNA AL161431.1 knockdown pancreatic cancer cells clearly indicated that lncRNA AL161431.1 is critical in the EMT process. The gene discussed is ELFN1; the disease is familial pancreatic carcinoma.