NEAT1 and colorectal carcinoma: Figure 1A illustrates that, in comparison with that in a normal cell line, NCM460, NEAT1 expression was dramatically increased within three CRC cell lines, HCT116, RKO, and LoVo, more upregulated in HCT116 and RKO cell lines. Thus, HCT116 and RKO cell lines were incubated with 0, 5, 10, or 20 mg/L 5-ALA (photosensitizer) and treated with PDT. Figure 1B shows that, along with the increases in 5-ALA doses, the repressive effects of PDT on CRC cell viability were enhanced. In the meantime, PDT treatment significantly downregulated NEAT1 expression in a 5-ALA dose-dependent manner (Figure 1C).