For these indicated CAF-related cytokines, the high expression level of EDIL3 correlated with poor prognosis in multiple tumors (39, 40); GRP was revealed to participate in CAF subtype transition in pancreatic ductal adenocarcinoma (PDAC) (41); IL16 polymorphisms were suggested to be associated with the high risk in types of cancer (42, 43), which were found to be regulated by the expression quantitative trait loci (eQTL) according to a genome-wide association study (GWAS) (44); PTN was also indicated to act as the downstream target of CDKN1A for a critical role in BC chemoresistance. This evidence concerns the gene IL16 and cancer.