DENND2B and breast cancer: Moreover, the mRNA expression of ST5 was notably decreased in breast cancer cells compared to that in normal MCF-10A cells, indicating lower ST5 levels in invasive cell lines (MDA-MB-231: a 50% fall; SKBR3: a 85% fall, P = 0.0001) than those in MCF-7 cells with a lower invasive capability (a 25% fall) (Figure 2E).