REN and Other metabolic disease: The angiotensin I converting enzyme 2 (Ace2) gene, which regulates systemic arterial blood pressure through the renin-angiotensin system, and the membrane metallo-endopeptidase (Mme) gene, that influences kidney development, are the DEGs found in this study, they play an important role in renin-angiotensin system and metabolic disorders related to the renin-angiotensin pathway were also observed.