PTCH1 and neoplasm: And there were missense mutations located in 6 tumor susceptibility genes, including PTCH1, BRCA2, BLM, ERCC4, BRCA1, and SETBP1 (Table S7), whose function loss have been closely associated with several hereditary tumor susceptibility syndromes (Acuna-Hidalgo et al., 2017; Qian et al., 2017; Romagnolo, Romagnolo & Selmin, 2015; Zhang et al., 2018).