Interestingly, preclinical central hypo-AF on NIR-AF in patients with confirmed BEST1 mutations were noted before any changes on SD-OCT or SW-AF evolved.[148,150] Parodi et al suggest this relates to RPE dysfunction and impaired melanin exocytosis and dispersion, leading to hypo-AF in NIR-AF.[128,150] Areas outside the central lesion do not display increased qAF levels, as opposed to STGD.[151]. The gene discussed is BEST1; the disease is atrial fibrillation.