No FAF pattern over the MNV has been shown to be predictive of outer retinal integrity.[85] However, the presence of an hyper-AF ring surrounding the MNV prior to injections has been associated with increased baseline SRF, increased number of injections, and greater likelihood of EZ disruption on HD-OCT after SRF resolution.[87] This ring suggests more widespread involvement than apparent on OCT or FA. The gene discussed is SRF; the disease is atrial fibrillation.