MAPT and Alzheimer disease: Based on the findings reported by Yang et al. [135], the resveratrol-encapsulated neuronal mitochondria-targeted micelle designed for their study was able to facilitate the delivery of high levels of resveratrol into the brain mitochondria; this efficiently reduced oxidative stress, decreased Aβ plaque formation, and ameliorated tau hyperphosphorylation, neuroinflammation, and declined memory function in an aged AD mice model.