SOD2 and colorectal cancer: In the most recent study on the antioxidant enzyme dichotomy, Gaya-Bover et al., assessed by western blot the levels of MnSOD, CuZnSOD, CAT (Catalase), GPx, and other proteins both in tumor and nontumor adjacent tissue from colorectal cancer patients found that nontumor adjacent tissue of had higher levels of antioxidants enzymes that detoxify H2O. However, tumor tissues showed higher levels of MnSOD and acetylated MnSOD that actually increased in stages II and III compared to stage I of malignancy and precancerous stage [171].