The administration of CoQ10 ameliorated the histopathological dysplastic changes, prevented the reduction of GSH and SOD activity, and significantly attenuated the expression of the nuclear factor-κB signaling pathway which enhances the transcription of TNF, iNOS, and COX-2 genes; CoQ10 reduced significantly both hepPar-1 and AFP immunomarkers of tumor in the liver cells of rats [223]. The gene discussed is PTGS2; the disease is neoplasm.