SOD1 and neoplasm: Into the bargain, (20 μg/mL) melatonin and (50 mg/j) capecitabine synergized together and improved survival and tumor growth inhibition in vivo in pancreatic tissue of male Syrian hamsters injected with the carcinogen N-nitroso bis(2-oxopropyl) amine (BOP), compared to capecitabine alone; this combination showed an upgrade in the antioxidant enzymes GSH, SOD, CAT, and GSH-Px activities and a retrogression of lipid peroxidation products [247].