Ferroptosis was a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels and had been implicated in the pathological cell death associated with degenerative diseases [42] Lipoxygenase- (Lox-) mediated generation of lipid peroxides enhanced ferroptosis induced by erastin and RSL3 [43]. The gene discussed is LOX; the disease is neurodegenerative disease.