SIRT1 and acute respiratory distress syndrome: Additionally, we found that Sirt1 deficiency also counteracted the antioxidant, anti-inflammatory, and antiapoptotic effects from Oxy in mice with ALI, which was evidenced by the increased TNF-α, the decreased SOD activity, and the increased ratio of Bax/Bcl-2 (Figures 7(c)–7(e)).