The results of immunohistochemistry showed that the expression of AKT (P = 0.0123), p-AKT (P = 0.0357), CREB (P = 0.0473), and p-CREB (P = 0.0256) in pancreatic ductal adenocarcinoma was lower than that of paracarcinoma (Figure 6). This evidence concerns the gene CREB1 and pancreatic ductal adenocarcinoma.