Decreased JP2 expression in the myocardium has been confirmed in various heart failure models, for instance, in a murine hypertrophic or dilated cardiomyopathy model [41], an I/R injury model [60], a rat hypertrophic cardiomyopathy model [61, 62], a murine myocardial infarction model [63], and a rat PH model [64, 65]. This evidence concerns the gene JPH2 and heart failure.