Tian et al. [84] reported that IDD was associated with upregulation of cGAS, STING, and NLRP3; moreover, pigallocatechin-3-gallate inhibited the cGAS/STING/NLRP3 pathway and exerted antiapoptotic and anti-inflammatory effects. The gene discussed is NLRP3; the disease is intervertebral disk degenerative disorder.