The results of KEGG pathway analysis highlighted nine pathways, in which target genes of ZSYTP acting on POI are enriched significantly; 33.33% of the enriched target genes act on viral carcinogenesis and 22.22% on the hypoxia-inducible factor 1 (HIF-1) signaling pathway; hepatocellular carcinoma, cell cycle, spliceosome, and ribosome pathways were equally divided at 11.11%. This evidence concerns the gene HIF1A and hepatocellular carcinoma.