The Venn analysis (Supplement S7) showed that PTGS2, PGR, BAX, CASP8, TGFB1, CASP3, BCL2, GSTP1, GSTM1, IL1B, MMP2, CDKN1A, POLD1, TP53, IL6, TNF, and ESR1, existed for all three core prescriptions and CRC. The gene discussed is ESR1; the disease is colorectal carcinoma.