Among the 27 regulatory proteins induced by spared nerve injury, the most significantly upregulated or downregulated proteins, respectively, were transmembrane protein 126A (TMEM126A) and excitatory amino acid transporter 2 (SLC1A2/EAAT2), which have mainly been associated with persistent pain, cognitive impairment, and immune-inflammatory regulation (Table 1). This evidence concerns the gene SLC1A2 and Cognitive impairment.