Substantial data from epidemiologic and experimental studies indicate an emerging association between hypruricemia, type 2 diabetes mellitus (T2DM), and cardiovascular-related diseases.8 Several studies revealed that hyperuricemia may be an independent risk factor for the development of T2DM 9–13, which suggest a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity) 13–15. This evidence concerns the gene INS and hyperuricemia.