The variation of a single Fok I restriction site may direct to ATG start cordon modification in second exon of vitamin D receptor while infinitesimal differences on the Bsm I site can manipulate the expression of protein33 consequently the polymorphisms which belongs to both genes were integrated in the current study, though, no considerable link was noted between T2DM and its onset and polymorphism of VDR (FokI, BsmI). The gene discussed is VDR; the disease is type 2 diabetes mellitus.