We observed negative correlation between serum 25(OH)VD3 concentrations and BMI (p=0.002), fasting glucose (p=0.031) waist circumference (p=0.023), HOMA-IR (p=0.006), LH (p=0.027), serum testosterone (p=0.012), and DHEAS (p=0.003) in women with PCOS. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.