We found that ERCC1 rs2298881 (C>A) gene polymorphism was not associated with overall survival of osteosarcoma (A allele: OR = 1.06, 95% CI: 0.38–2.96, P = 0.09; AA genotype: OR = 0.64, 95% CI: 0.36–1.14, P = 0.13; CC genotype: OR = 0.60, 95% CI: 0.09–4.02, P = 0.59). Here, ERCC1 is linked to osteosarcoma.