We found that ERCC1 rs11615 (19007 T>C) gene polymorphism was not associated with osteosarcoma risk (C allele: OR = 1.17, 95% CI: 0.86–1.58, P = 0.32; CC genotype: OR = 1.16, 95% CI: 0.70–1.93, P = 0.58; TT genotype: OR = 0.85, 95% CI: 0.63–1.15, P = 0.29). The gene discussed is ERCC1; the disease is osteosarcoma.