In our meta-analysis, we also assessed the relationship between ERCC gene polymorphism and osteosarcomas risk, and reported that ERCC1 rs3212986 (8092 C>A) gene polymorphism, ERCC1 rs11615 (19007 T>C) gene polymorphism, ERCC2 rs1799793 (A>G) gene polymorphism, ERCC2 rs13181 (Lys-751Gln) gene polymorphism were not associated with osteosarcoma risk. This evidence concerns the gene ERCC2 and osteosarcoma.