Our previous study38 performed a meta-analysis to evaluate the association between adiponectin polymorphisms and NAFLD susceptibility and the result suggested that adiponectin +45T>G and −11377C>G polymorphisms might be a risk factor for NAFLD, and +276G>T polymorphism may be a protective factor for NAFLD among Asians. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatotic liver disease.