There are many possible explanations for the mechanisms involve improvements in self-esteem and sleep quality following exercise training, some of the main biological mechanisms are reduced production of neuro-inflammatory factors that affect the main neuro-immune mechanisms potentially leading to symptoms of depression-like behavior53–55, also release of Beta endorphins56, the modification in serotonin function proposed by excessive neurotrophins, especially Brain Derived Neurotrophin Factor(BDNF) 57. Here, BDNF is linked to major depressive disorder.