To further demonstrate the mechanism of SOX2-OT targeting miR-30d-5p/PDK1 axis and its effect on NSCLC, A549 cells in each group were treated and divided into control group, sh-SOX2-OT group, sh-SOX2-OT + miR-30d-5p inhibitor group and sh-SOX2-OT + oe-PDK1 group, respectively. Here, SOX2 is linked to non-small cell lung carcinoma.