SOX2 and non-small cell lung carcinoma: The mechanism of SOX2-OT/miR-30d-5p/PDK1 axis on NSCLC cells was studied above, and it was confirmed that PDK1 acts on mTOR signaling pathway in NSCLC (Chen G. M. et al., 2018; Liu et al., 2019) and the activation of the pathway can drive PD-L1 in NSCLC (Lastwika et al., 2016).