Therefore, subsequently, we interpreted the immune escape of NSCLC cells mediated by PD-L1 and found that the expression of PD-L1 was decreased when SOX2-OT was silenced, and the co-culture results with CD8+ T cells revealed that silencing SOX2-OT would increase the percentage of CD8+ T cells and reduce the percentage of apoptotic cells. This evidence concerns the gene CD8A and non-small cell lung carcinoma.