COL6A1 and hyperinsulinemic hypoglycemia, familial, 4: Consistent with this, treatment with a MAO inhibitor (Menazza et al., 2010; Sorato et al., 2014) and treatment with a mitochondrial permeability transition pore inhibitor (Irwin et al., 2003; Merlini et al., 2008; Palma et al., 2009), reduced the apoptotic phenotype and improved mitochondrial function in Col6a1−/− mice and patients with collagen VI deficiency.