PRDM1 and neoplasm: Since a majority of TIL Tregs express Blimp1 in some tumor models (102), and Blimp1 is suggested to be used for outcome prediction of cancer patients (103), loss of Blimp1 in eTregs may reprogram these cells into Teff, and potentially lead to increased anti-tumor immunity and decreased tumor progression, although this awaits further investigation.