MX2 and HIV-1 infection: In this mini-review, we deliberate on interferon induced innate mechanisms against HIV-1 infection, exemplified by IFITM (Interferon Induced Transmembrane) proteins, APOBEC3 (Apolipoprotein B mRNA Editing enzyme Catalytic polypeptide like-3) proteins, MX2 (Myxovirus resistance-2), and ISG15 (Interferon Stimulated Gene-15) and highlight the current knowledge on the counter-mechanisms by which HIV-1 curtails the induction of innate cascade signaling as well as the restrictions posed by the RFs.