To this end, we generated a chimeric protein consisting of the ectodomain of MICA fused to a bacterial immunogenic protein that exhibits adjuvant properties (Brucella lumazine synthase, BLS), used this chimeric protein (named BLS-MICA) for the induction of anti-MICA Ab in tumor-bearing hosts, and investigated their therapeutic activity and mechanism of action. The gene discussed is MICA; the disease is neoplasm.