Blocking NKG2A with Monalizumab (a humanized anti-NKG2A mAb) enhances tumor immunity in combination with ICI against PD-L1 by promoting NK cell and CTL cell effector functions in mice and humans and enhances ADCC in combination with Cetuximab against a head and neck carcinoma cell line, indicating that its mechanism of action directly impacts on NK cell effector functions (192–194). This evidence concerns the gene KLRC1 and head and neck carcinoma.