One of these mAb (7C6) inhibited MICA and MICB shedding by human cancer cells, delayed the growth of mouse melanoma and colon carcinoma engineered to express MICA, reduced human melanoma metastases in a humanized mouse model and its mechanism of action involves the stimulation of NKG2D- and CD16-dependent NK cell-mediated effector functions (223). The gene discussed is MICB; the disease is melanoma.