While the constitutive loss of CD11chi cDCs reduced the generation of TH1 cells and TH2 cells as well as ILC1 and ILC3 in lymphoid tissues during the development of MC903-induced AD-like inflammation, it not only promoted the generation of ILC2 in lymphoid tissues but also enhanced serum productions of IgG and IgE, linking with increased emergence of IgM+ B cells, IgG1+ B cells, and IgE+ B cells in lymphoid tissues and decreased generation of IgM+ plasma cells and IgE+ plasma cells. Here, IGHE is linked to Alzheimer disease.