We measured CD8 T cell and bNAb suppression using CD4 and CD8 T cells isolated from 8 subjects with natural control of HIV infection (6 ES and 2 VC) and 5 different bNAbs that target the CD4 binding site (CD4bs), the V1-V2, or the membrane-proximal external region (MPER) of HIV Env (CD4bs: 3BNC117, VRC01, b12; V1-V2: PG9; MPER: 10E8). The gene discussed is CD4; the disease is HIV infectious disease.