Chronic periodontitis was associated with an increase of CRP and hs-CRP levels of 103% and 110%, respectively (p<0.0001) (RoM [95% CI]: 2.03 [1.59; 2.60], p<0.0001, I2 = 96.3% and RoM [95% CI]: 2.10 [1.62; 2.55], p<0.0001, I2 = 97.4%, respectively) (Table 1). Here, CRP is linked to chronic periodontitis.