CD4 and diabetes mellitus: When we transferred purified splenic CD4+ T cells alone or purified splenic neutrophils together with CD4+ T cells from BDC2.5+Il-10-/- NOD mice into Rag-/- NOD mice, no significant difference in the diabetes incidence was found, indicating that the altered neutrophils in BDC2.5+Il-10-/- NOD mice may contribute to the disease development, but not by direct effects on CD4+ T cells (Figure S7C).