Based on the expression of these genes in TCGA-CRC, we fitted a LASSO Cox regression model and identified 12 IRGs that were strongly predictive of RFS, including MFI2, LTA, VEGFA, NPY, SHC3, RAG1, CASP1, NTF3, COCH, NMB, ERN1, and NLRP7 (Figure 2A). This evidence concerns the gene NPY and colorectal carcinoma.