SHC3 and colorectal carcinoma: Based on the expression of these genes in TCGA-CRC, we fitted a LASSO Cox regression model and identified 12 IRGs that were strongly predictive of RFS, including MFI2, LTA, VEGFA, NPY, SHC3, RAG1, CASP1, NTF3, COCH, NMB, ERN1, and NLRP7 (Figure 2A).