SHC3 and neoplasm: In this study, we fitted a recurrence model consisting of 12 IRGs, including MFI2, LTA, VEGFA, NPY, SHC3, RAG1, CASP1, NTF3, COCH, NMB, ERN1, and NLRP7. All genes have been reported to be involved in the progression and TIME cross-talking of tumor.