Based on the expression of these genes in TCGA-CRC, we fitted a LASSO Cox regression model and identified 12 IRGs that were strongly predictive of RFS, including MFI2, LTA, VEGFA, NPY, SHC3, RAG1, CASP1, NTF3, COCH, NMB, ERN1, and NLRP7 (Figure 2A). The gene discussed is ERN1; the disease is colorectal carcinoma.