KEGG showed that LINC00973 might be involved in the regulation of MicroRNAs in cancer, RNA transport, TGF β signaling pathway, Cellular senescence, PI3K-Akt signaling pathway, Hippo signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, cell cycle and renin-angiotensin system and other signaling pathways (Figure 6D and Table 2). This evidence concerns the gene REN and cancer.