Nonspecific stimulation with LPS+CD40L+CpG-ODN resulted in a significant increase in total lymphocyte percentage (p=0.014) and significant reductions in the Bmem percentage and Bmem/Breg ratio (p=0.010 and 0.028, respectively) in the NMOSD group, while the T-cell percentage decreased in the MS group (p=0.017) (Supplementary Figure 1). This evidence concerns the gene CD40LG and myeloid sarcoma.