In order to verify whether the allergenic-related proteins identified in MPN following DMT were specifically stimulated in neurons (and not in both neurons and microglia), we compared the proteome of the anti-PrP antibody-treated microglia without co-culture with neurons and found that anti-PrP antibody-treated microglia only did not display any common allergy-related proteins with DMT (Table S7) indicating that our identified allergy-related proteins were specifically activated in neurons. This evidence concerns the gene PRNP and allergic disease.