Omp25, an outer membrane protein of Brucella, belonging to the group 3 proteins (Guzman-Verri et al., 2002; Vizcaino et al., 2004), is a Brucella key virulence factor (Glowacka et al., 2018) and is involved in the negative regulation of TNF-α production during infection of human macrophages (Jubier-Maurin et al., 2001). The gene discussed is SYNJ2BP; the disease is infection.