Upon DNA viruses [HSV-1 (10 MOI), PPV (1 MOI), PRV (1 MOI), and BoHV-1 (1 MOI)] infection or ISD (2 μg/ml) stimulation, IFN-βs were significantly induced in both mRNA and protein levels in THP-1, 3D4/21 cells, bovine PBMCs, and ovine PBMCs (Figures 2A–F), but we found that the levels of IFN-β mRNA in Lv-Omp25-infected cells were lower than that in Lv-GFP-infected various mammalian cells and control cells regardless of DNA viruses infection or ISD stimulation (Figures 2A,C,E,F). This evidence concerns the gene SYNJ2BP and infection.