A study conducted in Kuwait reported significantly lower levels of IGF-1 and IGFBP-3 in patients with coronary heart disease (CHD) and significant correlation between the level of IGFBP-3 and some metabolic markers including cholesterol, triglyceride (TG) and high-density lipoprotein (HDL) (45). This evidence concerns the gene IGFBP3 and coronary artery disorder.