In particular, two groups of chimeras, classic and attenuated, have been identified: chimeric genes where the junction site is located downstream of the c.293-13C/A>G mutation in the intron 2 (CH-1, CH-2, CH-3, CH-5, CH-6, CH-7, CH-8) are associated with the severe Salt Wasting form of CAH. This evidence concerns the gene C4B and congenital adrenal hyperplasia.