We then investigated laminin expression in humans using sWAT samples from female control subjects (BMI<30) and female subjects with obesity (BMI>35) undergoing bariatric surgery (baseline vs. 3 months post-surgery) and discovered that the expression of LAMA4 was significantly upregulated in the obese sWAT at both the mRNA and protein level. The gene discussed is LAMA4; the disease is obesity due to melanocortin 4 receptor deficiency.