The expression of chemokine receptor CXCR3 (28), lncRNA HNF1A-AS1 (29), and miR-206 (30) were identified to be associated with DM in osteosarcoma patients, and m6A-related signature (31), and tumor microenvironment (TME)-related signature (32) were constructed to have an early detection of DM. The gene discussed is HNF1A; the disease is osteosarcoma.