PRKAA1 and metabolic dysfunction-associated steatotic liver disease: An increase in the ratio of NAD+/NADH, results in the phosphorylation of LKB1 and AMPK which can activate the SIRT1/AMPK signaling pathway, inhibit adipogenesis and promote lipid oxidation, and reduce NAFLD symptoms and IR in HFD mice (Park et al., 2016).