Firstly, ethanol can increase the gene and protein expression of Lipin-1, induce Lipin-1-PAP activity and nucleocytoplasmic shuttling, inhibit Lipin-1-mediated fatty acid oxidation and VLDL-TG secretion in the liver, disrupt SIRT1-SFRS10 axis to affect Lpin1 alternative splicing, interfere with Lipin-1/NF-κB/NFATc4 axis, induce the production of pro-inflammatory cytokines, and finally lead to the development of AFLD in cultured hepatocytes and in mouse livers with alcoholic hepatitis (You et al., 2017). This evidence concerns the gene LPIN1 and alcoholic hepatitis.