2 PI3K/AKT/SREBP-1c signaling pathway is an important pathway for regulating lipid metabolism, which can reduce mitochondrial oxidative stress, inhibit adipogenesis, delay excessive lipid deposition, and alleviate hepatic steatosis (Abood et al., 2018; Liao et al., 2018; Pan et al., 2018). The gene discussed is AKT1; the disease is fatty liver disease.