Upstream, sympathetic hyperactivity, secondary to the micro-arousals and the intermittent hypoxia associated with OSA, increases glycogenolysis and liver neoglucogenesis; and intermittent hypoxia further promotes lipolysis that contributes to insulin resistance and worsens dysmetabolic nonalcoholic hepatopathy (Kent et al., 2014). The gene discussed is INS; the disease is obstructive sleep apnea syndrome.